The Pennsylvania SPCA (PSPCA) is a historic animal welfare organization located in Philadelphia, Pennsylvania. Founded in 1867, it was the first humane society in Pennsylvania and the second in the United States. The PSPCA was established to combat animal cruelty, initially focusing on the treatment of working horses and later expanding its mission to include all types of animals.

The PSPCA provides a range of services aimed at promoting animal welfare. It has humane law enforcement capabilities to investigate and prosecute animal cruelty cases. The organization operates an animal shelter that offers care and adoption services for homeless and injured animals. Additionally, it provides low-cost veterinary care, spay and neuter programs, and humane education initiatives to foster responsible animal care within the community. The PSPCA also engages in animal rescue and offers temporary boarding for pets in need. Through its comprehensive approach, the PSPCA works to improve the lives of animals across Pennsylvania.