Trans Lifeline is a trans-led, grassroots non-profit organization focused on providing emotional and financial support to transgender individuals in crisis. It operates a 24/7 crisis hotline staffed by trained trans operators, offering peer support that is independent of police or prison systems. This hotline is essential for trans people experiencing emotional distress, including suicide prevention.

In addition to crisis intervention, Trans Lifeline offers microgrants to address urgent financial needs within the trans community. The organization aims to connect trans individuals to vital resources and community care, promoting well-being and resilience. With a commitment to radical community care, Trans Lifeline has answered over 150,000 calls and dispersed nearly $1.5 million in funds. It serves transgender individuals nationwide, providing support in both English and Spanish, and emphasizes the importance of dignity and support for marginalized populations.